Synthesis and antiinflammatory properties of some novel thiazolidinones and imidazolidinones derived from 4-(3-phenyl-4(3H)-quinazolinon-2-yl)-3-thiosemicarbazone.

A series of quinazolinone thiazolidinone and imidazolidinone derivatives were prepared. These compounds were evaluated for their antiinflammatory activity. The most active compounds (6b, 6c and 6d) were found to be superior to phenylbutazone as they were devoid of any ulcerogenic activity.