Hendry J H, Potten C S, Merritt A
CRC Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK.
Radiat Environ Biophys. 1995 Mar;34(1):59-62. doi: 10.1007/BF01210548.
Cell death after irradiation occurs by apoptosis in certain cell populations in tissues. The phenomenon also occurs after high linear energy transfer (LET) irradiation, and the relative biological effectiveness (RBE) is 3 to 4 (with respect to low-LET radiation and apoptosis in intestinal crypts) for neutrons with energies of 14 MeV and up to 600 MeV. It is thought that p53 plays a role in the phenomenon, as radiation-induced apoptosis is not observed in p53-null animals.
照射后细胞死亡在组织中的某些细胞群体中通过凋亡发生。这种现象在高线性能量传递（LET）照射后也会出现，对于能量为14 MeV至600 MeV的中子，相对生物效能（RBE）为3至4（相对于低LET辐射和肠隐窝中的凋亡）。据认为，p53在该现象中起作用，因为在p53基因缺失的动物中未观察到辐射诱导的凋亡。
