Colombo L, Altomare S, Castelli M, Bestetti A, Stanzani M, Colombo N, Picollo S, Pietrasanta E R, Gnocchi P, Giavardi L
Day Hospital, Area Medica, Ospedale San Paolo, Milano.
Recenti Prog Med. 1995 May;86(5):204-7.
Nervous anorexia in advanced stage causes a generalized deterioration of organs' and apparatuses' functions. In particular, well-known are disorders of both CNS and PNS, changes of the haematic crasis and worsening of the metabolic-endocrine axis. Less well-known, however, is the compromission of function. Analysis of the data obtained in this trial points out a statistically significant correlation between the loss of weight and the variation of level of some liver enzymes (SGPT, SGOT, LDH). These indexes of hepatic necrosis in our opinion, can therefore, be regarded as sound markers not only for a more careful evaluation of the clinical evolution of the anorexic patient, but also for a better monitoring of the effectiveness of diet therapy.
晚期神经性厌食会导致器官和系统功能的全面衰退。特别是，中枢神经系统和外周神经系统的紊乱、血液成分的变化以及代谢 - 内分泌轴的恶化是众所周知的。然而，功能受损却鲜为人知。对本次试验所得数据的分析指出，体重减轻与某些肝酶（谷丙转氨酶、谷草转氨酶、乳酸脱氢酶）水平变化之间存在统计学上的显著相关性。因此，我们认为这些肝坏死指标不仅可作为更仔细评估厌食症患者临床进展的可靠标志物，还可用于更好地监测饮食疗法的效果。
