Ward M, Blatman M
Am Fam Physician. 1979 Feb;19(2):143-52.
Special considerations must be invoked when prescribing medications for the elderly. Although basic absorption is unchanged, many elderly patients are prone to chronic diarrhea or constipation, either of which may alter intestinal contact time and, thus, absorption. Concurrent use of such drugs as antacids or iron preparations may affect the availability of some compounds for absorption. The problem of drug interactions after absorption is also important, since studies have shown that elderly patients commonly receive several drugs concurrently.
给老年人开药时必须考虑特殊因素。虽然基本吸收情况不变,但许多老年患者容易出现慢性腹泻或便秘,这两种情况都可能改变药物在肠道内的接触时间,进而影响吸收。同时使用抗酸剂或铁制剂等药物可能会影响某些化合物的吸收。吸收后药物相互作用的问题也很重要,因为研究表明老年患者通常同时服用多种药物。