Shirota K, Masaki T, Kitada H, Yanagi M, Ikeda Y, Une Y, Nomura Y, Jothy S
Department of Veterinary Pathology, Azabu University, Kanagawa, Japan.
Vet Pathol. 1995 May;32(3):236-41. doi: 10.1177/030098589503200304.
Massive deposition of collagen fibrils was found in the renal glomeruli of two pigs. The affected pigs were a 6-month-old female hybrid pig with systemic mycobacteriosis and a retired sow showing azotemia. Microscopically, various amounts of a homogeneous eosinophilic substance were deposited within the expanded mesangium of almost all renal glomeruli in both cases. The deposit was also seen occasionally on the glomerular capillary walls in the sow. Capillary lumens were occluded in the glomerular segments with heavy deposition. Obsolescent glomeruli were often surrounded by lymphoid cells. The deposited substance was Congo red negative and stained deep blue with Heidenhain's azan staining. Immunohistochemical evaluation revealed that the major component of the homogeneous substance was type-III collagen. Electron microscopic examination showed that the deposits were masses of fibrils of variable length, width, and shape. The fibrils had transverse bands with a periodicity of approximately 60 nm, consistent with collagen fibrils. These glomerular changes were identical to those of collagenofibrotic glomerulonephropathy that has recently been described as a new glomerular disease in humans. The glomerular lesion may be the result of unusual production of type-III collagen by mesangial cells.
在两头猪的肾小球中发现大量胶原纤维沉积。患病猪一头是患有全身性分枝杆菌病的6月龄雌性杂种猪，另一头是出现氮血症的经产母猪。显微镜下，在两例病例中，几乎所有肾小球扩张的系膜内均有不同量的均匀嗜酸性物质沉积。在经产母猪的肾小球毛细血管壁上偶尔也可见到沉积物。沉积物较多的肾小球节段毛细血管腔被阻塞。废弃的肾小球常被淋巴细胞包围。沉积物质刚果红染色阴性，用海登海因氏偶氮蓝染色呈深蓝色。免疫组织化学评估显示，均匀物质的主要成分是III型胶原。电子显微镜检查显示，沉积物是由长度、宽度和形状各异的纤维束组成。这些纤维有周期性横纹，周期约为60纳米，与胶原纤维一致。这些肾小球变化与最近被描述为人类一种新的肾小球疾病的胶原纤维性肾小球肾炎相同。肾小球病变可能是系膜细胞异常产生III型胶原的结果。
