Shirota K, Nomura Y, Saito Y
Vet Pathol. 1984 Mar;21(2):158-63. doi: 10.1177/030098588402100204.
Spontaneous glomerulonephritis was found in seven six-month-old littermates from a leukemic sow. Light microscopy of the glomerular lesions showed proliferation of the mesangial cells and increase of the mesangial matrix with deposition of homogeneous materials. All glomeruli were affected, but the severity of the lesions varied among pigs. The glomerular capillary walls had local and segmental changes such as thickening and/or irregularity. Electron microscopy revealed dense deposits in the mesangial, paramesangial, subendothelial, subepithelial, and intramembranous areas. The mesangial and paramesangial deposits were most characteristic and prominent. In five of seven pigs, the clusters of extracellular spherical microparticles with a diameter ranging from 25 to 60 nm were observed in the subepithelial, intramembranous, subendothelial, and mesangial areas. No conspicuous lesions were noted in other organs.
在一头患白血病母猪的七只六个月大的同窝仔猪中发现了自发性肾小球肾炎。肾小球病变的光镜检查显示系膜细胞增生和系膜基质增加，伴有均匀物质沉积。所有肾小球均受影响，但病变严重程度在猪之间有所不同。肾小球毛细血管壁有局部和节段性改变，如增厚和/或不规则。电子显微镜显示系膜、旁系膜、内皮下、上皮下和膜内区域有致密沉积物。系膜和旁系膜沉积物最为典型和突出。在七头猪中的五头，上皮下、膜内、内皮下和系膜区域观察到直径为25至60纳米的细胞外球形微粒簇。其他器官未发现明显病变。
