Terry V, Murphy C R, Shorey C D
Department of Anatomy and Histology, University of Sydney, NSW, Australia.
Acta Anat (Basel). 1995;152(1):11-8. doi: 10.1159/000147678.
The interactive effects of clomiphene citrate (CC) and exogenous oestrogen (E2) or progesterone (P4), on the vaginal epithelium of ovariectomised rats were examined using scanning electron microscopy and light microscopy. Results were compared with P4E2 treatment. Statistical analysis showed no significant difference between the two combination CC treatments. All treatment groups had the ability to stimulate a dormant epithelium and cause surface modifications in the form of individually elongated microvilli and rosette formations. The results of this study indicate that while P4 enhances the oestrogenicity of CC, there is no cumulative oestrogenic effect when E2 and CC are combined, but there is modification of cell surface organisation and evidence of anti-oestrogenic activity.
利用扫描电子显微镜和光学显微镜，研究了枸橼酸氯米芬（CC）与外源性雌激素（E2）或孕酮（P4）对去卵巢大鼠阴道上皮的交互作用。将结果与P4E2处理组进行比较。统计分析表明，两种CC联合处理之间无显著差异。所有处理组均有刺激静止上皮并引起表面改变的能力，表现为单个伸长的微绒毛和玫瑰花结形成。本研究结果表明，虽然P4增强了CC的雌激素活性，但E2与CC联合使用时无累积雌激素效应，但存在细胞表面组织改变及抗雌激素活性证据。
