Olatunde B O, Onyemelukwe G C
Department of Medicine, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.
Afr J Med Med Sci. 1994 Sep;23(3):221-5.
T rosette cells results in patients with (Necator americanus and Ancylostoma duodenale) hookworm infection, divided into groups on the basis of the degree of anaemia (Group I had marked anaemia Hb 1-7, hypochromia ), Group II had moderate anaemia (Hb 8-11, hypochromia ++) and Group III had no signs of anaemia despite the underlying hookworm infection), were compared with results in 28 healthy controls who had no signs of other infection and excreting no ova of hookworm or other parasites. The level of sheep erythrocyte rosette-forming T-lymphocytes (SE-TL) in the patients (Group I:42 +/- 8%; Group II:45 +/- 11%; Group III:47 +/- 6%) was markedly reduced compared to controls (58 +/- 13%) (P < 0.001). The leucocyte migratory responses to purified protein derivative (P.P.D); were significantly (P < 0.05) reduced in all the subgroups as compared with the controls. The results support the hypothesis of the existence of immunosuppression in patients with hookworm infection.
对感染美洲板口线虫和十二指肠钩口线虫的患者的玫瑰花结细胞结果，根据贫血程度进行分组（第一组有明显贫血，血红蛋白1 - 7，低色素血症），第二组有中度贫血（血红蛋白8 - 11，低色素血症++），第三组尽管有潜在的钩虫感染但无贫血迹象），并与28名无其他感染迹象且未排出钩虫或其他寄生虫虫卵的健康对照者的结果进行比较。患者中绵羊红细胞玫瑰花结形成T淋巴细胞（SE - TL）水平（第一组：42±8%；第二组：45±11%；第三组：47±6%）与对照组（58±13%）相比明显降低（P < 0.001）。所有亚组中白细胞对纯化蛋白衍生物（PPD）的迁移反应与对照组相比均显著降低（P < 0.05）。这些结果支持钩虫感染患者存在免疫抑制的假说。
