Kogan E A, Shtabskiĭ A B, Sekamova S M, Mazurenko N N, Kiselev F L
Arkh Patol. 1994 Nov-Dec;56(6):44-9.
68 cases of lung carcinoma, 3 carcinoids and 15 fibrosing alveolitis with foci of adenomatosis and bronchiolo-alveolar carcinoma were studied. Oncoproteins c-fos, c-jun, c-ets-1, c-myc L and L-myc were identified in the tumour and surrounding tissue. Expression of c-fos was revealed in 79 of 138(59.4%) of proliferative and dysplastic changes of lung epithelium; c-jun in 40 of 61 (65.6%), c-ets-1 in 22 of 41 (53.7%), c-myc in 41 of 96(42.7%) and L-myc in 15 of 61 (24.6%), mainly in altered bronchial epithelium with a positive reaction to the antibodies against neuron specific enolase and S100 protein. More pronounced expression of nuclear oncoproteins, heterogeneity of their location in tissues, frequent cytoplasmic location in tumour cells were typical for lung carcinoma.
对68例肺癌、3例类癌以及15例伴有腺瘤样变和细支气管肺泡癌灶的肺纤维化肺泡炎进行了研究。在肿瘤及周围组织中鉴定出癌蛋白c-fos、c-jun、c-ets-1、c-myc L和L-myc。在138例肺上皮增殖和发育异常改变中，79例（59.4%）出现c-fos表达；61例中有40例（65.6%）出现c-jun表达，41例中有22例（53.7%）出现c-ets-1表达，96例中有41例（42.7%）出现c-myc表达，61例中有15例（24.6%）出现L-myc表达，主要出现在对神经元特异性烯醇化酶和S100蛋白抗体呈阳性反应的改变的支气管上皮中。核癌蛋白表达更明显、其在组织中的定位异质性、在肿瘤细胞中常见的细胞质定位是肺癌的典型特征。
