Conrad J T, Ueland K
Am J Obstet Gynecol. 1979 Jan 1;133(1):11-4. doi: 10.1016/0002-9378(79)90403-4.
A total of 62 strips of cervical tissue from 28 patients at term were tested for stiffness (stretch modulus) by elongation and measuring the tension produced by a given stretch. The stretch modulus was taken as the slope of the linear regression curve derived from the linear portion of the stress-strain relationship. The data were obtained from three patient categories: (1) 17 strips from seven patients undergoing spontaneous labor, (2) 18 strips form 10 patients with labor induced by PGE2, and (3) 27 strips from 11 patients with labor induced by oxytocin. The stretch moduli of cervical tissue obtained from spontaneous and oxytocin-induced labor patients were similar. The stretch moduli of cervical tissue obtained from PGE2-induced labor patients were significantly lower than those from either the spontaneous or the oxytocin-induced labor groups. These results show that PGE2, when used for induction of labor at term, has the ability to lower the stiffness of cervical tissue. This property of prostaglandin may be useful therapeutically for the indicated induction of labor in patients with an unfavorable cervix.
对28名足月患者的62条宫颈组织条带进行了拉伸试验，通过拉伸并测量给定拉伸产生的张力来测试其硬度（拉伸模量）。拉伸模量取应力-应变关系线性部分得出的线性回归曲线的斜率。数据来自三类患者：（1）7名自然分娩患者的17条组织条带，（2）10名使用PGE2引产患者的18条组织条带，（3）11名使用缩宫素引产患者的27条组织条带。自然分娩和缩宫素引产患者的宫颈组织拉伸模量相似。PGE2引产患者的宫颈组织拉伸模量显著低于自然分娩或缩宫素引产组。这些结果表明，足月引产时使用PGE2能够降低宫颈组织的硬度。前列腺素的这一特性在治疗上可能有助于对宫颈条件不佳的患者进行引产。
