Nishigaki I, Sasaguri Y, Yagi K
Institute of Applied Biochemistry, Gifu, Japan.
Atherosclerosis. 1995 Mar;113(2):167-70. doi: 10.1016/0021-9150(94)05442-l.
The proliferation of cultured smooth muscle cells from rabbit aorta was inhibited markedly by 2-methoxyestradiol, considerably by 2-hydroxyestradiol, and only slightly by 17 beta-estradiol. The effects at doses from 1 to 40 nmol/ml were cytostatic rather than cytocidal. 2-Methoxyestradiol could be useful to suppress excessive proliferation of arterial smooth muscle cells, and thus to prevent the progression of atherosclerosis.
