Mizuta E, Yamasaki S, Nakatake M, Kuno S
Department of Neurology, Utano National Hospital, Kyoto, Japan.
Neurology. 1993 May;43(5):1048-9. doi: 10.1212/wnl.43.5.1048.
A 45-year-old woman with Parkinson's disease developed neuroleptic malignant syndrome (NMS) despite lack of levodopa withdrawal. She experienced two episodes characterized by indomethacin-resistant hyperthermia, hyperhidrosis, and aggravation of parkinsonism. The symptoms, however, disappeared during menstruation. We suggest that the development of NMS may depend, in part, upon the hormonal state.
一名45岁的帕金森病女性患者，尽管未停用左旋多巴，仍发生了抗精神病药恶性综合征（NMS）。她经历了两次以吲哚美辛抵抗性高热、多汗以及帕金森症状恶化为特征的发作。然而，这些症状在月经期间消失。我们认为，NMS的发生可能部分取决于激素状态。
