Cottin Y, Maupoil V, Mezeray C, Brunotte F, Rochette L
Laboratoire de Physiopathologie et Pharmacologie Cardiovasculires Expérimentales, Facultés de Médecine et de Pharmacie, Dijon, France.
Cardioscience. 1995 Mar;6(1):39-45.
The purpose of this study was to evaluate changes in the proton nuclear magnetic resonance relaxation times (T1 and T2) after chronic infarction in the rat. Ligation of the left coronary artery was followed by various degrees of reduction in myocardial blood flow. The ligation induced infarction in the left ventricle and compensatory hypertrophy in the right ventricle, as evaluated by the ratio of right ventricle to body weight. The interventricular septum and the right ventricle did not become ischemic in this model and served as control areas. In the infarcted left ventricle our results showed an increase in the T1 and T2 relaxation times after 15 and 30 days of ligation and a slight decrease after 60 days. A similar change in the T1 values was observed in the right ventricle. In contrast, a persistent increase in the T2 relaxation times was observed in the right ventricle and correlated with the ratio of right ventricle to body weight (r = 0.54, p < 0.01). The observation that the magnetic resonance relaxation times in vitro are modified in the hypertrophic right ventricle after myocardial infarction could be important in interpreting magnetic resonance imaging in vivo. There was no relation between the changes in the relaxation times and the degree of myocardial ischemia.
本研究的目的是评估大鼠慢性心肌梗死后质子核磁共振弛豫时间（T1和T2）的变化。结扎左冠状动脉后，心肌血流量出现不同程度的减少。通过右心室与体重的比值评估，结扎导致左心室梗死和右心室代偿性肥大。在此模型中，室间隔和右心室未出现缺血情况，作为对照区域。在梗死的左心室中，我们的结果显示，结扎15天和30天后T1和T2弛豫时间增加，60天后略有下降。在右心室中观察到T1值有类似变化。相比之下，右心室中T2弛豫时间持续增加，并与右心室与体重的比值相关（r = 0.54，p < 0.01）。心肌梗死后肥厚的右心室中体外磁共振弛豫时间发生改变这一观察结果，对于解释体内磁共振成像可能具有重要意义。弛豫时间的变化与心肌缺血程度之间没有关系。
