Seitz R J, Huang Y, Knorr U, Tellmann L, Herzog H, Freund H J
Department of Neurology, Heinrich-Heine-University Düsseldorf, Germany.
Neuroreport. 1995 Mar 27;6(5):742-4. doi: 10.1097/00001756-199503270-00009.
The adult primate brain is capable of modifying rapidly the size of cortical receptive fields or motor output modules in response to altered synaptic input. We used positron emission tomography (PET) to map the regional cerebral blood flow changes related to voluntary finger movements in patients with tumours occupying the hand area of motor cortex. All patients showed activations solely outside the tumour. Compared with the unaffected side, the activations were shifted by 9-43 mm either along the mediolateral body representation of motor cortex or into premotor or parietal somatosensory cortex. These results provide evidence that slowly developing lesions can induce large-scale reorganization that is not confined to changes within the somatotopic body representation in motor cortex.
成年灵长类动物的大脑能够根据突触输入的改变迅速调整皮质感受野或运动输出模块的大小。我们使用正电子发射断层扫描（PET）来绘制与占据运动皮层手部区域的肿瘤患者的自主手指运动相关的局部脑血流变化。所有患者仅在肿瘤外显示激活。与未受影响的一侧相比，激活区域沿运动皮层的内外侧身体表征方向偏移了9 - 43毫米，或者转移到了运动前区或顶叶体感皮层。这些结果证明，缓慢发展的病变能够诱发大规模重组，这种重组并不局限于运动皮层躯体定位表征内的变化。
