Alpdogan O, Ozgun S, Lawrence R, Ozener C, Akoglu E, Akoglu T
Department of Haematology and Immunology, Marmara University Hospital, Istanbul, Turkey.
Intern Med. 1995 Apr;34(4):240-2. doi: 10.2169/internalmedicine.34.240.
The changes in mitogen-induced lymphocyte response occurring in nine patients undergoing chronic hemodialysis and treated with 1,25 dihydroxyvitamin D3 (0.5 micrograms/day) were investigated. Prior to treatment the stimulation indices (SI) in patients with 15.4 +/- 4.2 for phytohemagglutinin (PHA) and 7.2 +/- 0.7 for conconavalin A (Con A). In the controls, stimulation indices were 44.4 +/- 13.5 and 20.2 +/- 5.3 for PHA and Con A, respectively. Following treatment, the stimulation indices increased to 36.9 +/- 6.2 for PHA (p < 0.05) and 18.6 +/- 3.9 for Con A (p > 0.05) indicating the beneficial effect of oral 1,25 dihydroxyvitamin D3 treatment on lymphocyte function in patients with chronic renal failure.
对9例接受慢性血液透析并接受1,25-二羟维生素D3（0.5微克/天）治疗的患者丝裂原诱导淋巴细胞反应的变化进行了研究。治疗前，患者对植物血凝素（PHA）的刺激指数（SI）为15.4±4.2，对刀豆球蛋白A（Con A）的刺激指数为7.2±0.7。在对照组中，PHA和Con A的刺激指数分别为44.4±13.5和20.2±5.3。治疗后，PHA的刺激指数增至36.9±6.2（p<0.05），Con A的刺激指数增至18.6±3.9（p>0.05），表明口服1,25-二羟维生素D3治疗对慢性肾衰竭患者的淋巴细胞功能有有益作用。
