O'Mahony D, Denton J, Templar J, O'Hara M, Day J P, Murphy S, Walsh J B, Coakley D
Mercer's Institute for Research on Ageing, St. James's Hospital, Dublin, Ireland.
Dementia. 1995 Mar-Apr;6(2):69-72. doi: 10.1159/000106924.
The possible association between aluminium and Alzheimer's disease is still contentious. If aluminium neurotoxicity is implicated in the pathophysiology of Alzheimer's disease, it may result either from excessive aluminium exposure or increased brain aluminium uptake. In a pilot study to test the former hypothesis, trabecular bone aluminium content, which reflects long-term aluminium exposure, was evaluated in 7 patients with a clinical diagnosis of senile dementia of the Alzheimer type (SDAT; mean age 80.8 +/- 3.35 years) and 19 non-demented age-matched controls (mean age 79.6 +/- 6.09 years). Trabecular bone was obtained from post-traumatic femoral neck fracture specimens taken from patients during femoral head prosthesis surgery. Bone aluminium content was expressed quantitatively by atomic absorption spectrometry and qualitatively by the acid solochrome azurine histological staining technique. Quantitative analysis showed a lower aluminium content in the SDAT (11.9 +/- 4.04 micrograms/g dry bone) versus the non-demented group (18.2 +/- 7.37 micrograms/g), which was significant at the 95% but not at the 99% confidence limit. Aluminium deposition from qualitative histological analysis was not detectable in either group. These results do not support a hypothesis of excessive aluminium absorption and tissue accumulation in Alzheimer's disease.
铝与阿尔茨海默病之间可能存在的关联仍存在争议。如果铝神经毒性与阿尔茨海默病的病理生理学有关，那么其原因可能是铝暴露过量或大脑对铝的摄取增加。在一项检验前一种假设的初步研究中，对7例临床诊断为阿尔茨海默型老年性痴呆（SDAT；平均年龄80.8±3.35岁）的患者和19名年龄匹配的非痴呆对照者（平均年龄79.6±6.09岁）的小梁骨铝含量进行了评估，小梁骨铝含量反映长期铝暴露情况。小梁骨取自股骨头假体手术期间患者的创伤后股骨颈骨折标本。骨铝含量通过原子吸收光谱法定量测定，通过酸性溶剂蓝组织学染色技术定性测定。定量分析显示，SDAT组（11.9±4.04微克/克干骨）的铝含量低于非痴呆组（18.2±7.37微克/克），在95%置信区间有显著性差异，但在99%置信区间无显著性差异。两组的定性组织学分析均未检测到铝沉积。这些结果不支持阿尔茨海默病中铝吸收过量和组织蓄积的假设。
