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多关节炎大鼠心脏体外冠状动脉血管收缩：内皮素受体拮抗剂SB 209670体内治疗的效果

Coronary vasoconstriction in vitro in the hearts of polyarthritic rats: effectiveness of in vivo treatment with the endothelin receptor antagonist SB 209670.

作者信息

Klemm P, Warner T D, Willis D, Moore A R, Vane J R

机构信息

William Harvey Research Institute, Medical College of St. Bartholomew's Hospital, London.

出版信息

Br J Pharmacol. 1995 Apr;114(7):1327-8. doi: 10.1111/j.1476-5381.1995.tb13351.x.

DOI:10.1111/j.1476-5381.1995.tb13351.x
PMID:7606336
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1510275/
Abstract

Here we demonstrate that perfused hearts removed from polyarthritic rats develop a pronounced coronary vasoconstriction ex vivo. This vasoconstriction is almost entirely blocked by in vivo pretreatment of the rats with the endothelin receptor antagonist, SB 209670. Thus, inflammatory states may be associated with an increased activity of the endothelin system, leading to vascular dysfunction and vasoconstriction.

摘要

在此我们证明，从患多关节炎的大鼠体内取出并进行灌注的心脏在体外会出现明显的冠状动脉血管收缩。用内皮素受体拮抗剂SB 209670对大鼠进行体内预处理，几乎完全阻断了这种血管收缩。因此，炎症状态可能与内皮素系统活性增加有关，进而导致血管功能障碍和血管收缩。

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引用本文的文献

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Inflamm Res. 1996 Feb;45(2):51-3. doi: 10.1007/BF02265115.
2
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本文引用的文献

1
Phosphoramidon does not inhibit endogenous endothelin-1 release stimulated by hemorrhage, cytokines and hypoxia in rats.磷酰胺脒基酮并不抑制大鼠因出血、细胞因子和缺氧所刺激的内源性内皮素-1的释放。
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SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist.SB 209670，一种经合理设计的强效非肽类内皮素受体拮抗剂。
Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8052-6. doi: 10.1073/pnas.91.17.8052.
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Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis.类风湿关节炎中的细胞因子及细胞因子抑制剂或拮抗剂
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Changes in hepatic mRNA levels of acute phase proteins during rat adjuvant arthritis.大鼠佐剂性关节炎期间急性期蛋白肝脏mRNA水平的变化
Clin Exp Rheumatol. 1992 Sep-Oct;10(5):467-73.