依曲替酯作为光化学疗法治疗红皮病型皮肤T细胞淋巴瘤患者顽固性掌跖角化过度的有效辅助治疗方法。
Etretinate as an effective adjunctive therapy for recalcitrant palmar/plantar hyperkeratosis in patients with erythrodermic cutaneous T cell lymphoma undergoing photopheresis.
作者信息
Lim H W, Harris H R
机构信息
Dermatology Service, New York VA Medical Center, NY 10010, USA.
出版信息
Dermatol Surg. 1995 Jul;21(7):597-9. doi: 10.1111/j.1524-4725.1995.tb00513.x.
BACKGROUND
Patients with erythrodermic cutaneous T cell lymphoma (CTCL) frequently have debilitating hyperkeratosis of the palms and soles that is refractory to therapy.
OBJECTIVE
To evaluate the efficacy of etretinate as an adjunctive therapy for recalcitrant palmar and plantar hyperkeratosis in erythrodermic CTCL patients undergoing photopheresis.
METHODS
Five patients with erythrodermic CTCL and recalcitrant palmar and plantar hyperkeratosis were given etretinate (0.8 mg/kg per day) while undergoing photopheresis therapy.
RESULTS
There was a rapid and marked improvement of the hyperkeratosis in all patients.
CONCLUSION
Etretinate is a safe and effective adjunctive treatment for recalcitrant palmar and plantar hyperkeratosis in erythrodermic CTCL patients undergoing photopheresis.
背景
红皮病型皮肤T细胞淋巴瘤（CTCL）患者常出现手掌和足底令人虚弱的角化过度，且对治疗难治。
目的
评估依曲替酯作为辅助治疗对接受光化学疗法的红皮病型CTCL患者顽固性掌跖角化过度的疗效。
方法
5例红皮病型CTCL且伴有顽固性掌跖角化过度的患者在接受光化学疗法时给予依曲替酯（每天0.8mg/kg）。
结果
所有患者的角化过度均迅速且显著改善。
结论
依曲替酯对接受光化学疗法的红皮病型CTCL患者顽固性掌跖角化过度是一种安全有效的辅助治疗。
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