Lénárd L, Karádi Z, Faludi B, Czurkó A, Niedetzky C, Vida I, Nishino H
Neurophysiology Research Group, Hungarian Academy of Sciences, Pécs University, Medical School.
Brain Res Bull. 1995;37(2):149-55. doi: 10.1016/0361-9230(94)00269-7.
The lateral hypothalamic area (LHA) and globus pallidus (GP) are basically involved in the regulation of feeding and metabolic processes. In the LHA, glucose-sensitive (GS) neurons were described: their activity was found to be specifically suppressed by electrophoretic application of glucose, and these neurons appeared to be also influenced by various feeding-associated neurochemical signals. The main goal of the present experiments was to examine whether similar GS neurons exist in the GP. In addition, neurochemical attributes of the cells were also tested. In anesthetized rats and anesthetized or awake monkeys, single-neuron activity of the GP was recorded by means of carbon fiber multibarreled microelectrodes and the effects of glucose, glutamate (Gt), GABA, dopamine (DA), noradrenaline (NA) and acetylcholine (Ach) were studied. In both the rat and monkey GP, approximately 12% of the neurons examined responded, with inhibition, to glucose. GP neurons, in a high proportion, were also inhibited by GABA and NA. After application of Gt, DA, or Ach, activity increase or decrease occurred. GS neurons exhibited remarkable sensitivity to these neurochemicals previously identified as neurotransmitters of the complex pallidal, extrapyramidal-limbic neuron loops. The results, along with previous data, indicate that GS cells of the GP, while possessing complex neurochemical characteristics, may belong to a hierarchically organized central glucose-monitoring system essential in the regulation of feeding.
外侧下丘脑区域（LHA）和苍白球（GP）基本参与进食和代谢过程的调节。在LHA中，已描述了葡萄糖敏感（GS）神经元：发现通过电泳施加葡萄糖可特异性抑制它们的活动，并且这些神经元似乎也受各种与进食相关的神经化学信号的影响。本实验的主要目的是检查GP中是否存在类似的GS神经元。此外，还测试了这些细胞的神经化学特性。在麻醉大鼠以及麻醉或清醒的猴子中，通过碳纤维多管微电极记录GP的单神经元活动，并研究葡萄糖、谷氨酸（Gt）、γ-氨基丁酸（GABA）、多巴胺（DA）、去甲肾上腺素（NA）和乙酰胆碱（Ach）的作用。在大鼠和猴子的GP中，约12%的被检测神经元对葡萄糖有抑制反应。GP神经元中很大一部分也受到GABA和NA的抑制。施加Gt、DA或Ach后，活动会增加或减少。GS神经元对这些先前被确定为复杂苍白球、锥体外系-边缘神经元环路神经递质的神经化学物质表现出显著的敏感性。这些结果与先前的数据表明，GP的GS细胞虽然具有复杂的神经化学特征，但可能属于在进食调节中至关重要的分层组织的中央葡萄糖监测系统。
