通过荧光原位杂交将中国仓鼠主要组织相容性复合体（MHC）基因座定位到1号染色体的1q17→q18区域。

Localization of the Chinese hamster MHC locus to chromosome 1q17-->q18 by fluorescence in situ hybridization.

作者信息

Rassool F V, Neilly M E, McGuire K L, McKeithan T W, Le Beau M M

机构信息

Section of Hematology/Oncology, University of Chicago, IL, USA.

出版信息

Cytogenet Cell Genet. 1995;71(1):62-3. doi: 10.1159/000134064.

DOI:10.1159/000134064

PMID:7606930

Abstract

Comparative gene mapping analysis in mammals suggests that the major histocompatibility complex (MHC) genes map syntenic with genes, such as glyoxylase 1 (GLO1). In man, the MHC locus and other genes of this syntenic group map to chromosome band 6p21.3, and in mouse, these genes map to chromosome 17. In the hamster, however, only the GLO1 gene has been localized; GLO1 maps to chromosome 1, suggesting that the genes within the MHC locus also map to this chromosome. We have localized the hamster MHC class I genes to chromosome band 1q17-->q18 by fluorescence in situ hybridization (FISH). These results suggest that GLO1 and other syntenic genes also lie within this chromosome region.

摘要

哺乳动物中的比较基因图谱分析表明，主要组织相容性复合体（MHC）基因与诸如乙二醛酶1（GLO1）等基因在同一条染色体上连锁排列。在人类中，MHC基因座和该同线群的其他基因定位于染色体带6p21.3，而在小鼠中，这些基因定位于染色体17。然而，在仓鼠中，仅GLO1基因已被定位；GLO1定位于染色体1，这表明MHC基因座内的基因也定位于该染色体。我们通过荧光原位杂交（FISH）将仓鼠MHC I类基因定位于染色体带1q17→q18。这些结果表明，GLO1和其他同线基因也位于该染色体区域内。