Onofrj M, Fulgente T, Thomas A, Locatelli T, Comi G
Department of Neurology, University of Chieti, Italy.
Electroencephalogr Clin Neurophysiol. 1995 Jun;94(6):432-9. doi: 10.1016/0013-4694(94)00332-f.
In 6 patients with lesions of frontal, parietal and temporal lobe, in 4 patients affected by primary progressive aphasia (PPA) and in 56 age-matched controls, event-related potentials (ERPs) to an auditory odd-ball paradigm were recorded with the linked earlobe reference (LER) and with a computer calculated average reference (AR), excluding the two linked earlobe derivations. Latencies, amplitudes and scalp distribution of the earlier ERP components (P1, N1, P2, N2) were within normal limits for both LER and AR recordings. P300 scalp distribution in patients was normal when LER was used. When P300 was recorded using AR, the scalp distribution was statistically different from normal distributions in all patients. A negativity, instead of the positive P300 observed in controls, was recorded in patients from leads corresponding to the affected hemisphere.
在6例额叶、顶叶和颞叶病变患者、4例原发性进行性失语（PPA）患者以及56例年龄匹配的对照者中，采用耳垂导联参考（LER）和计算机计算的平均参考（AR，不包括两个耳垂导联的推导）记录听觉odd-ball范式的事件相关电位（ERP）。LER和AR记录的早期ERP成分（P1、N1、P2、N2）的潜伏期、波幅和头皮分布均在正常范围内。使用LER时，患者的P300头皮分布正常。当使用AR记录P300时，所有患者的头皮分布与正常分布在统计学上存在差异。在与患侧半球对应的导联中，患者记录到的是负波，而不是对照者中观察到的正性P300。
