Barnett A H
Undergraduate Centre, East Birmingham Hospital, UK.
Eye (Lond). 1993;7 ( Pt 2):218-22. doi: 10.1038/eye.1993.52.
The mechanism of development of microangiopathy is incompletely understood, but relates to a number of ultrastructural, biochemical and haemostatic processes. These include capillary basement membrane thickening, non-enzymatic glycosylation, possibly increased free radical activity, increased flux through the polyol pathway and haemostatic abnormalities. The central feature appears to be hyperglycaemia, which is causally related to the above processes and culminates in tissue ischaemia. This article will briefly describe these processes and will discuss possible pathogenic interactions which may lead to the development of the pathological lesion.
微血管病变的发病机制尚未完全明确，但与一些超微结构、生化及止血过程有关。这些过程包括毛细血管基底膜增厚、非酶糖基化、自由基活性可能增加、多元醇途径通量增加以及止血异常。核心特征似乎是高血糖，它与上述过程存在因果关系，最终导致组织缺血。本文将简要描述这些过程，并讨论可能导致病理损伤发生的致病相互作用。
