催乳素对西咪替丁的反应。
Prolactin responses to cimetidine.
作者信息
Burland W L, Gleadle R I, Lee R M, Rowley-Jones D, Groom G V
出版信息
Br J Clin Pharmacol. 1979 Jan;7(1):19-21. doi: 10.1111/j.1365-2125.1979.tb00891.x.
Abstract
1 An intravenous injection of cimetidine 400 mg to four healthy male subjects resulted in high blood concentrations of cimetidine and a rapid three-fold increase in serum prolactin. 2 This effect was prevented by pretreatment with bromocriptine. 3 No increase in prolactin followed a single oral dose of cimetidine 800 mg administered to a different group of healthy male subjects. The mean peak blood concentration of cimetidine was less than 20% of that achieved with 400 mg i.v. 4 Only isolated reports have been received of gynaecomastia or galactorrhoea occurring during cimetidine treatment. In three of seven cases studied there was associated hyperprolactinaemia. This may be an idiosyncratic response at the lower blood concentration of cimetidine associated with oral therapeutic dose regimens.
摘要
- 对四名健康男性受试者静脉注射400毫克西咪替丁后，其血液中西咪替丁浓度升高，血清催乳素迅速增加了三倍。2. 溴隐亭预处理可防止这种效应。3. 对另一组健康男性受试者单次口服800毫克西咪替丁后，催乳素没有增加。西咪替丁的平均血药峰浓度低于静脉注射400毫克时所达到浓度的20%。4. 仅收到关于西咪替丁治疗期间发生男性乳房发育或溢乳的个别报告。在七例研究病例中有三例伴有高催乳素血症。这可能是与口服治疗剂量方案相关的西咪替丁血药浓度较低时的一种特异反应。
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本文引用的文献
1
Letter: Breast changes in males on cimetidine.信函：西咪替丁治疗男性患者时的乳房变化
N Engl J Med. 1976 Oct 7;295(15):841. doi: 10.1056/NEJM197610072951514.
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The absorption of cimetidine before and during maintenance treatment with cimetidine and the influence of a meal on the absorption of cimetidine--studies in patients with peptic ulcer disease.西咪替丁维持治疗前后的吸收情况以及进餐对西咪替丁吸收的影响——对消化性溃疡病患者的研究
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The measurement of human gonadotrophins by radioimmunoassay.采用放射免疫分析法测定人促性腺激素。
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Plasma-prolactin and cimetidine.血浆催乳素与西咪替丁
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High-pressure liquid chromatographic analysis of cimetidine, a histamine H2-receptor antagonist, in blood and urine.
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