口服拉贝洛尔降压作用的起效速率。
Rate of onset of hypotensive effect of oral labetalol.
作者信息
Serlin M J, Orme M C, Maciver M, Green G J, Macnee C M, Breckenridge A M
出版信息
Br J Clin Pharmacol. 1979 Feb;7(2):165-8. doi: 10.1111/j.1365-2125.1979.tb00916.x.
Abstract
1 Labetalol caused a fall in blood pressure within 2 h or oral doses of 100, 200 and 400 mg in six hypertensive patients. 2 This fall which was dose-related was maximal by 3 h and was sustained when the drug was given in doses of 100 mg 8 hourly, 200 mg 8 hourly and 400 mg 8 hourly. 3 This rapid fall in pressure when labetalol is given by mouth which contrasts to that seen on administration of pure beta-adrenoceptor blocking agents is a valuable therapeutic property.
摘要
- 拉贝洛尔对6名高血压患者口服100、200和400毫克剂量后，2小时内可使血压下降。2. 这种下降与剂量相关，3小时时达到最大降幅，当每8小时给予100毫克、每8小时给予200毫克和每8小时给予400毫克剂量的药物时，血压降幅持续存在。3. 口服拉贝洛尔时血压迅速下降，这与使用纯β - 肾上腺素能受体阻滞剂时的情况形成对比，是一种有价值的治疗特性。
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本文引用的文献
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Immediate hemodynamic effects of beta-adrenergic blockade with propranolol in normotensive and hypertensive man.普萘洛尔对血压正常和高血压男性进行β-肾上腺素能阻滞的即时血流动力学效应。
Circulation. 1968 Mar;37(3):411-6. doi: 10.1161/01.cir.37.3.411.
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Pharmacology of AH 5158; a drug which blocks both - and -adrenoceptors.AH 5158的药理学；一种能阻断α和β肾上腺素能受体的药物。
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