Sautner D, Saeger W
Abteilung für Pathologie, Marienkrankenhaus Hamburg.
Fortschr Med. 1995 May 20;113(14):207-9.
A total of 39 specimens of urine were tested for tumor cells using a monoclonal antibody (mab 486p 3/12, "medaquic"). Of these specimens, 18 were obtained from patients with histologically confirmed transitional cell carcinoma. All these specimens were also examined morphologically for the presence of atypical cells, and 25 specimens using a monoclonal antibody against CEA. The "medaquic" test showed a 77.8% sensitivity for detecting transitional cell carcinoma (conventional cytology: 61.1%). The percentage of false-positives with the "medaquic" test was 33.3% (2/6): the results of conventional cytology were similar; two GI carcinomas were not detected by "medaquic". The antigen for the mab 486p 3/12 is a CEA-like glycoprotein. The "medaquic" test was positive appreciably more often than was the CEA antibody reaction.
总共39份尿液标本使用单克隆抗体（mab 486p 3/12，“medaquic”）检测肿瘤细胞。在这些标本中，18份取自组织学确诊为移行细胞癌的患者。所有这些标本也进行了形态学检查以确定是否存在非典型细胞，另外25份标本使用了抗CEA单克隆抗体进行检测。“medaquic”检测对检测移行细胞癌的敏感性为77.8%（传统细胞学：61.1%）。“medaquic”检测的假阳性率为33.3%（2/6）：传统细胞学结果相似；“medaquic”未检测出2例胃肠道癌。mab 486p 3/12的抗原是一种CEA样糖蛋白。“medaquic”检测呈阳性的情况明显比CEA抗体反应更常见。
