Vyssoulis G P, Valiouli M A, Karpanou E A, Toutouzas P K
Department of Cardiology, University of Athens, Greece.
Int J Cardiol. 1995 Mar 24;49(1):45-54. doi: 10.1016/0167-5273(95)02283-3.
Using echocardiographic and Doppler methodology, we evaluated the effects of celiprolol 200-400 mg/day and metoprolol 100-200 mg/day, given for one year, on haemodynamics, left ventricular structure and function, and aortic root distensibility in 40 hypertensive patients. Total peripheral resistance was unchanged with metoprolol (-1.7%) but decreased with celiprolol (-11.2%), a significant difference between the two treatments (P = 0.01). Left ventricular mass index was reduced by 5.7% in those patients receiving metoprolol and by 11.8% in those receiving celiprolol (P < 0.001). Cardiac index fell significantly with metoprolol and marginally with celiprolol (-13.9% vs. 5.9%, P = 0.003). Left ventricular diastolic function-as shown by the transmitral early to late peak filling velocity ratio-was not altered with metoprolol, but a significant increase (17%, P = 0.2) was seen with celiprolol. Both metoprolol and celiprolol increased aortic root distensibility, with celiprolol having a significantly greater effect (80% vs. 30%, P < 0.01). We conclude that, in comparison to metoprolol, long term antihypertensive therapy with celiprolol improves left ventricular diastolic and aortic root function, whilst reducing total peripheral resistance and left ventricular hypertrophy.
我们采用超声心动图和多普勒方法，评估了40例高血压患者每日服用200 - 400毫克塞利洛尔和100 - 200毫克美托洛尔，持续一年对血流动力学、左心室结构与功能以及主动脉根部扩张性的影响。美托洛尔治疗后总外周阻力无变化（-1.7%），而塞利洛尔治疗后总外周阻力降低（-11.2%），两种治疗方法之间存在显著差异（P = 0.01）。接受美托洛尔治疗的患者左心室质量指数降低了5.7%，接受塞利洛尔治疗的患者左心室质量指数降低了11.8%（P < 0.001）。美托洛尔使心脏指数显著下降，塞利洛尔使心脏指数略有下降（-13.9% 对 5.9%，P = 0.003）。以二尖瓣舒张早期与晚期峰值充盈速度比值表示的左心室舒张功能，美托洛尔治疗后未改变，但塞利洛尔治疗后显著增加（17%，P = 0.2）。美托洛尔和塞利洛尔均增加了主动脉根部扩张性，塞利洛尔的作用显著更大（80% 对 30%，P < 0.01）。我们得出结论，与美托洛尔相比，长期使用塞利洛尔进行抗高血压治疗可改善左心室舒张功能和主动脉根部功能，同时降低总外周阻力和左心室肥厚。
