Subramanian R, Chilla R
HNO-Klinik, Zentralkrankenhaus St. -Jürgen-Strasse, Bremen.
HNO. 1995 May;43(5):299-303.
Fifty-eight patients presenting with lymph node metastases of the head and neck were treated at the Bremen ENT Clinic from 1970 to 1988. In none of the patients could a primary tumor be detected despite extensive diagnostic procedures. The 5-year survival rate was 26.3%. During the further course of the disease, six primary tumors were detected in the following areas: nasopharynx (2 cases), soft palate, oesophagus, bronchi and kidney. Prognosis decreased with increasing tumor stages, although histological grading had no influence on prognosis. Supraclavicular localization and male sex were high risk factors. Prognosis was also not improved when ampiric irradiation also included the pharynx as a possible site of the primary tumor.
1970年至1988年期间，不来梅耳鼻喉诊所对58例出现头颈部淋巴结转移的患者进行了治疗。尽管进行了广泛的诊断程序，但在这些患者中均未检测到原发肿瘤。5年生存率为26.3%。在疾病的进一步发展过程中，在以下部位检测到6例原发肿瘤：鼻咽（2例）、软腭、食管、支气管和肾脏。尽管组织学分级对预后没有影响，但预后随着肿瘤分期的增加而降低。锁骨上淋巴结定位和男性是高危因素。当经验性放疗也将咽部作为原发肿瘤的可能部位时，预后也没有改善。
