Johnstone P A, DeLuca A M, Bacher J D, Hampshire V A, Terrill R E, Anderson W J, Kinsella T J, Sindelar W F
Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Int J Radiat Oncol Biol Phys. 1995 Jul 15;32(4):1031-4. doi: 10.1016/0360-3016(95)00028-w.
The clinical late effects of intraoperative radiotherapy (IORT) on peripheral nerve were investigated in a foxhound model.
Between 1982 and 1987, 40 animals underwent laparotomy with intraoperative radiotherapy of doses from 0-75 Gy administered to the right lumbosacral plexus. Subsequently, all animals were monitored closely and sacrificed to assess clinical effects to peripheral nerve. This analysis reports final clinical results of all animals, with follow-up to 5 years.
All animals treated with > or = 25 Gy developed ipsilateral neuropathy. An inverse relationship was noted between intraoperative radiotherapy dose and time to neuropathy, with an effective dose for 50% paralysis (ED50) of 17.2 Gy. One of the animals treated with 15 Gy IORT developed paralysis, after a much longer latency than the other animals.
Doses of 15 Gy delivered intraoperatively may be accompanied by peripheral neuropathy with long-term follow-up. This threshold is less than that reported with shorter follow-up. The value of ED50 determined here is in keeping with data from other animal trials, and from clinical trials in humans.
在猎狐犬模型中研究术中放疗（IORT）对周围神经的临床晚期效应。
1982年至1987年间，40只动物接受了剖腹手术，术中对右侧腰骶丛给予0 - 75 Gy的放疗剂量。随后，对所有动物进行密切监测并处死，以评估对周围神经的临床效应。本分析报告了所有动物的最终临床结果，随访时间长达5年。
所有接受≥25 Gy治疗的动物均出现同侧神经病变。术中放疗剂量与神经病变发生时间呈负相关，50%瘫痪的有效剂量（ED50）为17.2 Gy。接受15 Gy IORT治疗的一只动物出现瘫痪，但其潜伏期比其他动物长得多。
术中给予15 Gy的剂量在长期随访中可能会伴有周围神经病变。该阈值低于随访时间较短时报告的阈值。此处确定的ED50值与其他动物试验及人类临床试验的数据一致。
