在缺乏磷的大肠杆菌细胞中鸟苷3',5'-双焦磷酸（ppGpp）的合成
Guanosine 3',5'-bispyrophosphate (ppGpp) synthesis in cells of Escherichia coli starved for Pi.
作者信息
Spira B, Silberstein N, Yagil E
机构信息
Department of Biochemistry, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Israel.
出版信息
J Bacteriol. 1995 Jul;177(14):4053-8. doi: 10.1128/jb.177.14.4053-4058.1995.
Abstract
Cells of Escherichia coli which enter a phase of starvation for Pi induce the synthesis of the nucleotide guanosine 3',5'-bispyrophosphate (ppGpp). This induction is relA independent but depends on the spoT gene product. A mutant unable to produce ppGpp is impaired in the expression of two genes which belong to the pho regulon, a defect which is dependent on the product of spoT. We suggest that ppGpp is essential for the proper induction of the genes which belong to the pho regulon.
摘要
进入磷饥饿阶段的大肠杆菌细胞会诱导合成核苷酸鸟苷 3',5'-双焦磷酸（ppGpp）。这种诱导不依赖于relA，但依赖于spoT基因产物。无法产生ppGpp的突变体在属于pho调节子的两个基因的表达上存在缺陷，这种缺陷依赖于spoT的产物。我们认为ppGpp对于正确诱导属于pho调节子的基因至关重要。
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