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本文引用的文献

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Guanosine tetraphosphate inhibits protein synthesis in vivo. A possible protective mechanism for starvation stress in Escherichia coli.四磷酸鸟苷在体内抑制蛋白质合成。大肠杆菌中饥饿应激的一种可能保护机制。
J Biol Chem. 1993 Feb 5;268(4):2307-11.
2
Survival of hunger and stress: the role of rpoS in early stationary phase gene regulation in E. coli.饥饿与应激下的存活：rpoS在大肠杆菌稳定早期基因调控中的作用
Cell. 1993 Jan 29;72(2):165-8. doi: 10.1016/0092-8674(93)90655-a.
3
Role of the sigma 70 subunit of RNA polymerase in transcriptional activation by activator protein PhoB in Escherichia coli.RNA聚合酶的σ70亚基在大肠杆菌中激活蛋白PhoB介导的转录激活中的作用。
Genes Dev. 1993 Jan;7(1):149-60. doi: 10.1101/gad.7.1.149.
4
Synthesis of the stationary-phase sigma factor sigma s is positively regulated by ppGpp.固定相σ因子σs的合成受到ppGpp的正调控。
J Bacteriol. 1993 Dec;175(24):7982-9. doi: 10.1128/jb.175.24.7982-7989.1993.
5
Use of the rep technique for allele replacement to construct mutants with deletions of the pstSCAB-phoU operon: evidence of a new role for the PhoU protein in the phosphate regulon.使用重复技术进行等位基因替换以构建缺失pstSCAB-phoU操纵子的突变体：PhoU蛋白在磷酸盐调节子中的新作用证据。
J Bacteriol. 1993 Nov;175(21):6797-809. doi: 10.1128/jb.175.21.6797-6809.1993.
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The role of the sigma factor sigma S (KatF) in bacterial global regulation.σ因子σS（KatF）在细菌全局调控中的作用。
Annu Rev Microbiol. 1994;48:53-80. doi: 10.1146/annurev.mi.48.100194.000413.
7
spoT-dependent accumulation of guanosine tetraphosphate in response to fatty acid starvation in Escherichia coli.在大肠杆菌中，spoT 依赖的鸟苷四磷酸积累对脂肪酸饥饿的响应。
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11004-8. doi: 10.1073/pnas.90.23.11004.
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Complete analysis of cellular nucleotides by two-dimensional thin layer chromatography.通过二维薄层色谱法对细胞核苷酸进行完整分析。
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9
Effects of starvation for potassium and other inorganic ions on protein degradation and ribonucleic acid synthesis in Escherichia coli.饥饿对大肠杆菌中钾及其他无机离子的影响及其对蛋白质降解和核糖核酸合成的作用。
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On the regulation of guanosine tetraphosphate levels in stringent and relaxed strains of Escherichia coli.关于大肠杆菌严谨型和松弛型菌株中鸟苷四磷酸水平的调控
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在缺乏磷的大肠杆菌细胞中鸟苷3',5'-双焦磷酸（ppGpp）的合成

Guanosine 3',5'-bispyrophosphate (ppGpp) synthesis in cells of Escherichia coli starved for Pi.

作者信息

Spira B, Silberstein N, Yagil E

机构信息

Department of Biochemistry, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Israel.

出版信息

J Bacteriol. 1995 Jul;177(14):4053-8. doi: 10.1128/jb.177.14.4053-4058.1995.

DOI:10.1128/jb.177.14.4053-4058.1995
PMID:7608079
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC177136/
Abstract

Cells of Escherichia coli which enter a phase of starvation for Pi induce the synthesis of the nucleotide guanosine 3',5'-bispyrophosphate (ppGpp). This induction is relA independent but depends on the spoT gene product. A mutant unable to produce ppGpp is impaired in the expression of two genes which belong to the pho regulon, a defect which is dependent on the product of spoT. We suggest that ppGpp is essential for the proper induction of the genes which belong to the pho regulon.

摘要

进入磷饥饿阶段的大肠杆菌细胞会诱导合成核苷酸鸟苷 3',5'-双焦磷酸（ppGpp）。这种诱导不依赖于relA，但依赖于spoT基因产物。无法产生ppGpp的突变体在属于pho调节子的两个基因的表达上存在缺陷，这种缺陷依赖于spoT的产物。我们认为ppGpp对于正确诱导属于pho调节子的基因至关重要。