细胞周期蛋白A将c-Myc与非黏附依赖性细胞增殖联系起来。
Cyclin A links c-Myc to adhesion-independent cell proliferation.
作者信息
Barrett J F, Lewis B C, Hoang A T, Alvarez R J, Dang C V
机构信息
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
出版信息
J Biol Chem. 1995 Jul 7;270(27):15923-5. doi: 10.1074/jbc.270.27.15923.
Adhesion-independent growth is a neoplastic phenotype that is inducible in Rat 1a fibroblasts by enforced MYC expression. The c-Myc protein has been well characterized as a transcription factor, yet the molecular basis of c-Myc-induced neoplastic transformation has remained elusive. In this report, we demonstrate a link between ectopic MYC expression, deregulated cyclin A levels, and adhesion-independent growth.
非粘附性生长是一种肿瘤表型，通过强制表达MYC可在大鼠1a成纤维细胞中诱导产生。c-Myc蛋白已被充分表征为一种转录因子，然而c-Myc诱导肿瘤转化的分子基础仍然难以捉摸。在本报告中，我们证明了异位MYC表达、细胞周期蛋白A水平失调与非粘附性生长之间的联系。
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