Raĭtsina S S, Kurnosov A V, Iarovaia I M, Gladkova N S, Davydova A I
Biull Eksp Biol Med. 1979 Jan;87(1):44-8.
Partial decrease of venous drainage from the left testis in male rats induced development of destructive changes in the seminiferous epithelium at the site of operation and in the contralateral organ. Spermatogenesis disturbances in the rat testes (focal desquamation of seminiferous epithelium, disorganization and degeneration of germ cells, devastation of seminiferous tubules) resembles the lesion in men with varicocele. These data permit to consider the results of present experiment as varicocele modelling. Disturbance of permeability and of the fine blood-testis barrier structure in both testes was observed in experimental rats; the picture of morphological changes was similar to that of autoimmune orchitis; lymphocytes sensitized to spermatozoa antigens were revealed in the lymphoid organs of experimental rats. The results obtained permit to suggest the involvement of immunological mechanisms in the development of pathological changes in the testes affected with varicocele.
雄性大鼠左侧睾丸静脉引流部分减少，导致手术部位及对侧器官的生精上皮出现破坏性改变。大鼠睾丸的生精障碍（生精上皮局灶性脱屑、生殖细胞紊乱和变性、生精小管破坏）类似于精索静脉曲张男性的病变。这些数据使得本实验结果可被视为精索静脉曲张模型。在实验大鼠中观察到双侧睾丸通透性及精细血睾屏障结构的破坏；形态学变化情况与自身免疫性睾丸炎相似；在实验大鼠的淋巴器官中发现了对精子抗原致敏的淋巴细胞。所得结果提示免疫机制参与了精索静脉曲张所致睾丸病理变化的发生发展。
