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Autoantibodies against beta-crystallins induce lens epithelial cell damage and cataract formation in mice.

作者信息

Singh D P, Guru S C, Kikuchi T, Abe T, Shinohara T

机构信息

Center for Ophthalmic Research, Brigham and Women's Hospital/Harvard Medical School, Boston, MA 02115, USA.

出版信息

J Immunol. 1995 Jul 15;155(2):993-9.

PMID:7608574
Abstract

One-year-old B6C3/f mice, injected with beta-crystallins emulsified with CFA, developed lens epithelial cell damage. Both serum transfer and mAb transfer studies clearly established that the autoimmune insult is induced by humoral immunity. Older mice were more susceptible to autoimmune insult than younger animals. Lens epithelial cell damage invariably proceeded to cortical and posterior subcapsular cataract formation. This mouse model of experimental autoimmune cataract formation will facilitate the exploration of the relation between immune phenomena and human age-related cataract.

摘要

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