Tonstad S, Ose L, Gørbitz C, Djøseland O, Bard J M, Fruchart J C
Medical Department A, National Hospital, Oslo, Norway.
J Intern Med. 1995 Jul;238(1):39-47. doi: 10.1111/j.1365-2796.1995.tb00897.x.
To test the efficacy of hormone replacement therapy (HRT) and dietary therapy, compared to dietary therapy, in lowering LDL cholesterol levels among postmenopausal women.
A prospective parallel randomized study of sequential 17 beta-oestradiol and norethisterone acetate or placebo for 48 weeks.
A University outpatient lipid clinic.
A total of 76 postmenopausal women, aged 43-60 years, with LDL cholesterol levels > or = 4.2 mmol 1-1, treated with a lipid-lowering diet.
Levels of lipids, lipoproteins, apolipoproteins, fibrinogen and glucose tolerance.
Adherence to the diet was similar in both groups. Total and LDL cholesterol levels were reduced by 14% (95% CI, 11-17%) and 19% (95% CI, 14-23%), respectively, in the HRT group vs. 3% (95% CI, 0-7%) and 5% (95% CI, 0-11%) in the diet group. HRT reduced the levels of apolipoprotein B and lipoprotein(a). Levels of HDL cholesterol, HDL2, HDL3, triglycerides, lipoprotein populations and apolipoproteins AI and AII remained unchanged. No adverse effects on glucose tolerance or on fibrinogen levels were observed. The reduction in LDL cholesterol was positively correlated with initial levels of LDL cholesterol and negatively correlated with body mass index.
HRT is effective in reducing elevated LDL cholesterol levels, and should be considered in the treatment of hyperlipidaemic postmenopausal women, in addition to dietary therapy.
与饮食疗法相比，测试激素替代疗法（HRT）在降低绝经后女性低密度脂蛋白胆固醇水平方面的疗效。
一项前瞻性平行随机研究，连续使用17β-雌二醇和醋酸炔诺酮或安慰剂治疗48周。
大学门诊脂质诊所。
共有76名年龄在43 - 60岁之间、低密度脂蛋白胆固醇水平≥4.2 mmol/L的绝经后女性，接受降脂饮食治疗。
血脂、脂蛋白、载脂蛋白、纤维蛋白原和葡萄糖耐量水平。
两组对饮食的依从性相似。HRT组的总胆固醇和低密度脂蛋白胆固醇水平分别降低了14%（95%可信区间，11 - 17%）和19%（95%可信区间，14 - 23%），而饮食组分别降低了3%（95%可信区间，0 - 7%）和5%（95%可信区间，0 - 11%）。HRT降低了载脂蛋白B和脂蛋白(a)的水平。高密度脂蛋白胆固醇、HDL2、HDL3、甘油三酯、脂蛋白群体以及载脂蛋白AI和AII的水平保持不变。未观察到对葡萄糖耐量或纤维蛋白原水平有不良影响。低密度脂蛋白胆固醇的降低与初始低密度脂蛋白胆固醇水平呈正相关，与体重指数呈负相关。
HRT在降低升高的低密度脂蛋白胆固醇水平方面有效，除饮食疗法外，在治疗绝经后高脂血症女性时应予以考虑。
