Dungar C F, Wilkinson E J
Woman's Health Specialists, Appleton, Wisconsin, USA.
J Reprod Med. 1995 May;40(5):361-6.
Vaginal adenosis, with columnar epithelium of endocervical or endometrial type forming glands within the vagina, has been observed as a congenitally acquired process, associated with in utero exposure to diethylstilbestrol; approximately 20% of those women exposed in utero have adenosis. It has been observed that vaginal adenosis may occur in nonexposed women; the origin is thought to be acquired following puberty. This study analyzed eight patients who, following topical vaginal therapy with 5-fluorouracil for vaginal intraepithelial neoplasia, had unresolving, reddened areas in the upper one-third of the vagina. Biopsy of these areas demonstrated columnar epithelium on the vaginal surface, where stratified squamous epithelium would be expected. Superficial vaginal glands (adenosis) lined with epithelium identical to the surface columnar epithelium were also identified. This finding is consistent with a metaplastic process in which stratified squamous epithelium is replaced by columnar representing columnar cell metaplasia, or acquired vaginal adenosis.
阴道腺病表现为阴道内出现由宫颈内膜型或子宫内膜型柱状上皮形成的腺体，这一病症可通过先天性获得，与子宫内接触己烯雌酚有关；约20%在子宫内接触过己烯雌酚的女性患有腺病。据观察，阴道腺病也可能发生在未接触过己烯雌酚的女性身上；其发病被认为是青春期后获得的。本研究分析了8例患者，这些患者在接受5-氟尿嘧啶局部阴道治疗阴道上皮内瘤变后，阴道上三分之一处出现了持续不消退的发红区域。对这些区域进行活检显示，在预期为复层鳞状上皮的阴道表面出现了柱状上皮。还发现了表面有与表面柱状上皮相同上皮的浅表阴道腺体（腺病）。这一发现与化生过程一致，即复层鳞状上皮被柱状上皮取代，代表柱状细胞化生，也就是获得性阴道腺病。
