小鼠纤维蛋白原样蛋白与鼠肝炎病毒诱导的凝血酶原酶活性的关联。
Association of mouse fibrinogen-like protein with murine hepatitis virus-induced prothrombinase activity.
作者信息
Parr R L, Fung L, Reneker J, Myers-Mason N, Leibowitz J L, Levy G
机构信息
Department of Pathology, University of Texas Medical School at Houston 77225, USA.
出版信息
J Virol. 1995 Aug;69(8):5033-8. doi: 10.1128/JVI.69.8.5033-5038.1995.
Abstract
Previously, we demonstrated induction of a unique macrophage prothrombinase during infection of BALB/cJ mice by mouse hepatitis virus strain 3 (MHV-3). By immunologic screening, a clone representing this prothrombinase was isolated from a cDNA library and sequenced. The sequence identified this clone as representing part of a gene, musfiblp, that encodes a fibrinogen-like protein. Six additional clones were isolated, and one clone, p11-3-1, encompassed the entire coding region of musfiblp. Murine macrophages did not constitutively express musfiblp but, when infected with MHV-3, synthesized musfiblp-specific mRNA. musfiblp mRNA induction was earlier and significantly greater in BALB/cJ than A/J macrophages. Prothrombinase activity was demonstrated when musfiblp was expressed from p11-3-1 in RAW 264.7 cells. These data suggest that musfiblp encodes the MHV-induced prothrombinase.
摘要
此前，我们证明了在小鼠肝炎病毒3型（MHV-3）感染BALB/cJ小鼠期间可诱导产生一种独特的巨噬细胞凝血酶原酶。通过免疫筛选，从一个cDNA文库中分离出代表这种凝血酶原酶的一个克隆并进行了测序。该序列确定这个克隆代表一个基因（musfiblp）的一部分，该基因编码一种纤维蛋白原样蛋白。又分离出另外6个克隆，其中一个克隆p11-3-1包含了musfiblp的整个编码区。小鼠巨噬细胞并非组成性表达musfiblp，但在感染MHV-3时会合成musfiblp特异性mRNA。BALB/cJ巨噬细胞中musfiblp mRNA的诱导比A/J巨噬细胞更早且显著更强。当从p11-3-1在RAW 264.7细胞中表达musfiblp时，可证明有凝血酶原酶活性。这些数据表明musfiblp编码了MHV诱导的凝血酶原酶。
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