多克隆猫抗体对猫免疫缺陷病毒的中和作用：表面糖蛋白高变区4和5的同时参与
Neutralization of feline immunodeficiency virus by polyclonal feline antibody: simultaneous involvement of hypervariable regions 4 and 5 of the surface glycoprotein.
作者信息
Siebelink K H, Huisman W, Karlas J A, Rimmelzwaan G F, Bosch M L, Osterhaus A D
机构信息
Institute of Virology, Erasmus University Rotterdam, The Netherlands.
出版信息
J Virol. 1995 Aug;69(8):5124-7. doi: 10.1128/JVI.69.8.5124-5127.1995.
Abstract
Sites involved in antibody-mediated neutralization of feline immunodeficiency virus were mapped by reciprocal exchange of envelope fragments or amino acids between molecular clones of feline immunodeficiency virus with different susceptibilities to neutralization by a polyclonal cat serum. Combinations of mutations within HV-4 or within HV-4 and HV-5 changed the susceptibility of the viruses to neutralizing antibody.
摘要
通过对不同中和敏感性的猫免疫缺陷病毒分子克隆之间的包膜片段或氨基酸进行相互交换，绘制了参与抗体介导的猫免疫缺陷病毒中和作用的位点。HV-4内或HV-4与HV-5内的突变组合改变了病毒对中和抗体的敏感性。
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