Guan Z, Kiruluta G, Coolsaet B, Elhilali M
Department of Urology, Norman Bethune University of Medical Science, Chang Chun, China.
J Urol. 1995 Aug;154(2 Pt 1):580-6. doi: 10.1097/00005392-199508000-00074.
The aim of our study was to create reproducible partial bladder outlet obstruction and to evaluate the resulting urodynamic changes.
Thirty-one female Yucatan microswine were randomly divided into obstructed and control groups. In the obstructed group of 21 animals, an artificial 4.5-cm. sphincter cuff was placed around the bladder neck. Fourteen of these minipigs were eventually deobstructed. In the controls (unobstructed sham-operated group), the sphincter cuff was removed prior to closure. Urodynamic measurements were conducted at 2, 4, 8 and 12 weeks postobstruction in conscious animals restrained in specially designed adjustable cages.
(with all pressures in cm.H2O): 1) Unobstructed sham controls: Pdet,open 28.8 Pdet (Qmax) 22.5, Qmax 30.8 ml. per second, Pdet,isv 61.7, urethral resistance relation (URA) 7.7 cm.H2O, and Watts factor (WF) 4.7 W/m.2; 2) Obstructed group: Pdet,open 85.2; Pdet (Qmax) 94.4, Qmax 5.6 ml. per second, Pdet,isv 135.2, mean URA 74.3 cm.H2O and WF 13.5 W/m.2; 3) Deobstructed group: Pdet,open 39.9, Pdet (Qmax) 25.9, Qmax 25.0 ml. per second, Pdet,isv 58.0, mean URA 8.9 cm.H2O and WF 5.4 W/m.2.
This animal model of reversible infravesical obstruction has given consistent and reproducible pressure flow data in the conscious, upright state.
本研究的目的是创建可重复的部分膀胱出口梗阻模型，并评估由此产生的尿动力学变化。
31只雌性尤卡坦小型猪被随机分为梗阻组和对照组。在21只动物的梗阻组中，在膀胱颈周围放置一个4.5厘米的人工括约肌套。其中14只小型猪最终解除梗阻。在对照组（未梗阻的假手术组）中，在关闭前移除括约肌套。在梗阻后2、4、8和12周，对置于特殊设计的可调节笼子中的清醒动物进行尿动力学测量。
（所有压力单位为厘米水柱）：1）未梗阻的假手术对照组：开放时膀胱压力（Pdet,open）28.8，最大尿流率时膀胱压力（Pdet (Qmax)）22.5，最大尿流率（Qmax）30.8毫升/秒，膀胱内压（Pdet,isv）61.7，尿道阻力关系（URA）7.7厘米水柱，以及瓦茨因子（WF）4.7瓦/平方米；2）梗阻组：Pdet,open 85.2；Pdet (Qmax) 94.4，Qmax 5.6毫升/秒，Pdet,isv 135.2，平均URA 74.3厘米水柱和WF 13.5瓦/平方米；3）解除梗阻组：Pdet,open 39.9，Pdet (Qmax) 25.9，Qmax 25.0毫升/秒，Pdet,isv 58.0，平均URA 8.9厘米水柱和WF 5.4瓦/平方米。
这种可逆性膀胱下梗阻动物模型在清醒、直立状态下给出了一致且可重复的压力流数据。
