Watson H S, Bauer S B, Peters C A, Mandell J, Colodny A H, Atala A, Retik A B
Department of Surgery, Children's Hospital, Boston, Massachusetts, USA.
J Urol. 1995 Aug;154(2 Pt 2):878-82. doi: 10.1097/00005392-199508000-00152.
We report the cystometric and conduit pressure profilometric findings of 20 children for whom the Mitrofanoff principle was applied to the construction of 21 continent catheterizable urinary conduits. Mitrofanoff conduits were fashioned from ureter in 10 cases, appendix in 8, ileum in 1, stomach in 1 and a combination appendix and ureter in 1. Conduit pressure profiles showed that functional profile length correlated strongly with the static profile maximal Mitrofanoff closure pressure (p = 0.04) and dynamic profile maximal Mitrofanoff closure pressure (p = 0.02). There was a statistically significant difference between clinical continence rates for children above and below the functional profile length threshold of 2.0 cm. (p = 0.05). The zone of continence corresponded to the region of the conduit intramural tunnel. Only 2 of 21 conduits were incontinent but both were constructed with ureters implanted into bowel reservoirs. Compared to appendiceal conduits, ureteral conduits had a lower functional profile length (p < 0.01) and static profile maximal Mitrofanoff closure pressure (p < 0.01), indicating a possible advantage to the use of the appendix.
我们报告了20名儿童的膀胱测压和导管压力轮廓测量结果，这些儿童应用米氏原理构建了21条可控性尿流改道导管。10例米氏导管由输尿管制成，8例由阑尾制成，1例由回肠制成，1例由胃制成，1例由阑尾和输尿管组合制成。导管压力轮廓显示，功能轮廓长度与静态轮廓最大米氏闭合压力（p = 0.04）和动态轮廓最大米氏闭合压力（p = 0.02）密切相关。功能轮廓长度阈值为2.0 cm以上和以下儿童的临床控尿率存在统计学显著差异（p = 0.05）。控尿区域与导管壁内隧道区域相对应。21条导管中只有2条出现尿失禁，但这两条均是将输尿管植入肠储尿囊构建而成。与阑尾导管相比，输尿管导管的功能轮廓长度（p < 0.01）和静态轮廓最大米氏闭合压力（p < 0.01）较低，这表明使用阑尾可能具有优势。
