Cornelison T L, Goldberg J M, Piver M S
Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
J Surg Oncol. 1995 Jul;59(3):204-8. doi: 10.1002/jso.2930590314.
Pancreatic cancer and jejunal cancer are aggressive diseases with grim prognoses. The long term survival of pancreatic carcinoma is still one of the worst of all cancers. Ninety-five percent of the patients die of their disease within 5 years [Wagener et al: Ann Oncol 5(Suppl 3): S87-S90, 1994]. Eighty-five percent of patients with jejunal carcinoma die of their disease within 5 years [Lioe, Biggart: J Clin Pathol 43:533-536, 1990]. To date, there are disappointingly few effective cytotoxic agents in the treatment of these cancers. We present a case of advanced-stage pancreatic carcinoma and a case of advanced stage jejunal carcinoma, each showing marked response to Taxol and platinum chemotherapy.
胰腺癌和空肠癌是侵袭性疾病，预后严峻。胰腺癌的长期生存率在所有癌症中仍然是最差的之一。95%的患者在5年内死于该疾病[瓦格纳等人：《肿瘤学年鉴》5（增刊3）：S87 - S90，1994]。85%的空肠癌患者在5年内死于该疾病[廖伊、比加特：《临床病理学杂志》43：533 - 536，1990]。迄今为止，在治疗这些癌症方面，有效的细胞毒性药物少得令人失望。我们报告1例晚期胰腺癌和1例晚期空肠癌病例，二者对紫杉醇和铂类化疗均表现出显著反应。
