在酵母双杂交系统中，细胞朊蛋白（PrP）可选择性地与Bcl-2结合。
The cellular prion protein (PrP) selectively binds to Bcl-2 in the yeast two-hybrid system.
作者信息
Kurschner C, Morgan J I
机构信息
Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110, USA.
出版信息
Brain Res Mol Brain Res. 1995 May;30(1):165-8. doi: 10.1016/0169-328x(95)00013-i.
Bcl-2 can rescue neurons from death and might, therefore, exert its action by associating with neuron-specific proteins. Using LexA-Bcl-2 as bait, we find that the cellular prion protein (PrP) interacts with Bcl-2, but not Bax, in the yeast two-hybrid system. Since the PrP gene has been implicated in neurodegenerative disorders, this preliminary observation suggests a potential pathogenic mechanism for these conditions.
Bcl-2可使神经元免于死亡，因此可能通过与神经元特异性蛋白结合来发挥其作用。以LexA-Bcl-2为诱饵，我们发现在酵母双杂交系统中，细胞朊蛋白（PrP）与Bcl-2相互作用，但不与Bax相互作用。由于PrP基因与神经退行性疾病有关，这一初步观察结果提示了这些疾病可能的致病机制。
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