Antolak J A, Mah E, Scrimger J W
Cross Cancer Institute, Edmonton, Alberta, Canada.
Med Phys. 1995 Apr;22(4):411-9. doi: 10.1118/1.597606.
The pencil beam method of calculating dose distributions for electron-beam radiotherapy has been very useful, however, several limitations in the approach have been recognized. One such limitation is the lack of a mechanism to model range straggling of electrons. For stationary electron-beam calculations, range straggling is incorporated incompletely in the planar-fluence-to-dose conversion factor, which uses measured percentage depth dose curves to force the calculated percentage depth dose to reproduce the measurement. When calculating the dose distribution for an arced beam using a pencil beam algorithm, insufficient modeling of the pencil beams leads to larger errors than when using a stationary beam algorithm. The calculated depth of maximum dose is systematically over-estimated by the pencil beam calculations. We will show that the lack of a way to account for range straggling in the arc-electron pencil beam calculation is primarily responsible for this discrepancy. Methods of incorporating range straggling into the electron pencil beam dose calculation have been presented before, but no data have been shown to support their use for heterogeneous phantoms (patients). This paper presents a similar range-straggling modification, as well as data to show that this model can predict pencil beam width to within 20% for heterogeneous slab phantoms. For stationary electron-beam calculations, the calculated isodose lines follows the measured isodose lines to within 1 mm down to the 10% dose level.(ABSTRACT TRUNCATED AT 250 WORDS)
用于电子束放射治疗剂量分布计算的笔形束方法一直非常有用,然而,人们已经认识到该方法存在一些局限性。其中一个局限性是缺乏对电子射程歧离进行建模的机制。对于静止电子束计算,射程歧离在平面注量-剂量转换因子中未被完全纳入,该因子使用测量的百分深度剂量曲线来迫使计算出的百分深度剂量重现测量值。当使用笔形束算法计算弧形束的剂量分布时,笔形束建模不足会导致比使用静止束算法时更大的误差。笔形束计算会系统性地高估计算出的最大剂量深度。我们将表明,在弧形电子笔形束计算中缺乏考虑射程歧离的方法是造成这种差异的主要原因。之前已经提出了将射程歧离纳入电子笔形束剂量计算的方法,但尚未有数据支持它们用于非均匀体模(患者)。本文提出了一种类似的射程歧离修正方法,以及数据表明该模型可以将非均匀平板体模的笔形束宽度预测在20%以内。对于静止电子束计算,计算出的等剂量线在剂量水平降至10%时与测量的等剂量线相差在1毫米以内。(摘要截短为250字)