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Activation of dopamine D1 receptors enhances long-term depression of synaptic transmission induced by low frequency stimulation in rat hippocampal CA1 neurons.

作者信息

Chen Z, Fujii S, Ito K, Kato H, Kaneko K, Miyakawa H

机构信息

Department of Physiology, Zhejiang Medical University, Hangzhou, People's Republic of China.

出版信息

Neurosci Lett. 1995 Mar 31;188(3):195-8. doi: 10.1016/0304-3940(95)11430-5.

DOI:10.1016/0304-3940(95)11430-5
PMID:7609907
Abstract

The effects of both activation and blockade of dopamine (DA) D1 receptors on long-term depression (LTD) of synaptic transmission were examined in CA1 neurons of rat hippocampal slices. Low frequency stimulation (LFS) consisting of 450 pulses at 1 Hz induced LTD (-14.3%, mean, n = 10) in the slope of the field excitatory postsynaptic potential. SKF-38393 (3-10 microM), an agonist of DA D1 receptors, significantly enhanced LFS-induced LTD (-31.1%, n = 11). SCH-23390 (2 microM), an antagonist of DA D1 receptors, blocked the induction of LTD by LFS (2.5%, n = 6). These results indicate that DA D1 receptors play an important role in the modulation of LFS-induced LTD in rat hippocampal CA1 neurons.

摘要

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