Benazzouz A, Piallat B, Pollak P, Benabid A L
Laboratoire de Neurobiophysique, UJFG, INSERM U.318, Centre Hospitalier Universitaire de Grenoble, France.
Neurosci Lett. 1995 Apr 14;189(2):77-80. doi: 10.1016/0304-3940(95)11455-6.
High frequency stimulation of the subthalamic nucleus (STN-HFS) has been shown to reverse parkinsonian motor symptoms in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys. We have studied the effect of STN-HFS on the spontaneous activity of the substantia nigra pars reticulata (SNr), entopeduncular nucleus (EP) and globus pallidus (GP) in rats. STN-HFS induced a decrease in activity of 91% of SNr cells, a suppression of activity in 80% of EP cells and an activation of 100% of GP recorded cells. These results show that STN-HFS exerts an inhibitory influence on the basal ganglia output structures similar to that obtained by STN lesion.
高频刺激丘脑底核（STN-HFS）已被证明可逆转1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）处理的猴子的帕金森运动症状。我们研究了STN-HFS对大鼠黑质网状部（SNr）、脚内核（EP）和苍白球（GP）自发活动的影响。STN-HFS使91%的SNr细胞活动减少，80%的EP细胞活动受到抑制，100%记录的GP细胞活动被激活。这些结果表明，STN-HFS对基底神经节输出结构产生抑制作用，类似于STN损伤所产生的作用。
