Fallon P G, Hamilton J V, Doenhoff M J
School of Biological Sciences, University of Wales, Bangor, Gwynedd, UK.
Parasitology. 1995 Jul;111 ( Pt 1):59-66. doi: 10.1017/s003118200006460x.
The reduction in worm burden obtained by treatment of Schistosoma mansoni with praziquantel and oxamniquine was greater in mice with heavy infections than in relatively lightly infected animals. The reduction in worm burden achieved by each drug correlated with the size of the pre-treatment worm burden (r2 = 0.82 and 0.81 for praziquantel and oxamniquine, respectively). Intensity of infection did not affect the degree of tegumental damage and drug-induced antigen exposure on worms recovered soon after treatment with praziquantel. However, praziquantel-treated worms from mice with heavy infections had significantly more murine antibody attached to the treated-worm surface than worms from praziquantel-treated lightly infected mice. Heavily infected mice had greater levels of circulating anti-worm antibodies than lighter infected mice. The correlation between infection intensity and cure rates achieved by praziquantel and oxamniquine may thus be a reflection of the higher titres of relevant antibody in heavily infected mice mediating death of drug-treated worms.
用吡喹酮和奥沙尼喹治疗曼氏血吸虫，重度感染小鼠的虫负荷降低程度大于相对轻度感染的动物。每种药物导致的虫负荷降低与治疗前虫负荷大小相关（吡喹酮和奥沙尼喹的r2分别为0.82和0.81）。感染强度不影响吡喹酮治疗后不久回收的虫体的体表损伤程度和药物诱导的抗原暴露。然而，重度感染小鼠经吡喹酮治疗后的虫体表面附着的鼠抗体明显多于轻度感染小鼠经吡喹酮治疗后的虫体。重度感染小鼠的循环抗虫抗体水平高于轻度感染小鼠。因此，感染强度与吡喹酮和奥沙尼喹治愈率之间的相关性可能反映了重度感染小鼠中相关抗体的较高滴度介导了药物治疗后虫体的死亡。
