Motles E, Tetas M, Gomez A
Departamento de Medicina Experimental Oriente, Facultad de Medicina, Universidad de Chile, Santiago.
Physiol Behav. 1995 May;57(5):983-8. doi: 10.1016/0031-9384(94)00310-2.
The aim of the present work was to study the behavioral effects elicited in adult cats by the selective D1 agonist, SKF 38393, and the D2 agonist, LY 171555, comparing their effects with those evoked by apomorphine. In 10 adult cats, 0.5, 1.0, 4.0, and 8.0 mg/kg IP of SKF 38393 were administered at random. A dose-response effect was observed related to alertness, indifference, and locomotion. The overall effect of SKF 38393 was inhibitory. To the same 10 animals, LY 171555 in doses of 0.25, 0.5, and 1.0 mg/kg were injected IP. This drug had an excitatory and more complex effect than what was observed with the D1 agonist. Increases in locomotion, in alertness, indifference, fear, olfaction, pupillary dilation, hallucination, limb flicking, and head shaking were recorded. Apomorphine given to the same cats, in a dose equimolar to 1.0 mg/kg of LY 171555, elicited behaviors that resembled those elicited by the latter drug, but of a lesser intensity and duration. The interval between the different treatments was approximately 2 months. These results show clearly that the D2 receptor is the main dopaminergic receptor involved in the mechanism of production of most of the behavioral effects produced by some of the dopaminergic agonist drugs like apomorphine.
本研究的目的是研究选择性D1激动剂SKF 38393和D2激动剂LY 171555对成年猫产生的行为影响，并将它们的作用与阿扑吗啡所引发的作用进行比较。对10只成年猫随机腹腔注射0.5、1.0、4.0和8.0mg/kg的SKF 38393。观察到与警觉、淡漠和运动相关的剂量反应效应。SKF 38393的总体效应是抑制性的。对同样的10只动物腹腔注射剂量为0.25、0.5和1.0mg/kg的LY 171555。该药物产生的是兴奋性作用，且比D1激动剂所观察到的作用更复杂。记录到运动、警觉、淡漠、恐惧、嗅觉、瞳孔散大、幻觉、肢体轻弹和摇头增加。给同样的猫注射与1.0mg/kg LY 171555等摩尔剂量的阿扑吗啡，所引发的行为与后一种药物引发的行为相似，但强度和持续时间较小。不同处理之间的间隔约为2个月。这些结果清楚地表明，D2受体是参与某些多巴胺能激动剂药物（如阿扑吗啡）产生的大多数行为效应机制的主要多巴胺能受体。
