Lambert K G, Kinsley C H, Jones H E, Klein S L, Peretti S N, Stewart K M
Department of Psychology, Randolph-Macon College, Ashland, VA 23005, USA.
Physiol Behav. 1995 May;57(5):989-94. doi: 10.1016/0031-9384(94)00340-b.
In the present study, 28 pregnant rats were subjected to either light-restraint stress or no manipulation for days 14-21 of the gestational period. At approx. 50 days of age, both male (n = 16) and female (n = 16) prenatally stressed (PS) and control offspring were subjected to the activity stress (AS) paradigm. During this subsequent stress experience, PS rats developed less ulceration than control rats. PS rats also displayed about half the activity of the control animals during the habituation phase of the AS paradigm, prior to the induction of stress. Given this decrease in baseline activity in PS animals, implications of using activity as a measure of emotionality in PS animals are discussed. Several sex differences were also observed; females differed from males in that they 1) exhibited higher activity levels in both the habituation and experimental phases of the AS procedure, 2) developed heavier relative adrenal weights, and 3) reached criteria for sacrifice in fewer days.
在本研究中，28只怀孕大鼠在妊娠期的第14至21天接受轻度束缚应激或不进行任何处理。在大约50日龄时，将雄性（n = 16）和雌性（n = 16）的产前应激（PS）子代及对照子代进行活动应激（AS）范式实验。在随后的这种应激经历中，PS大鼠形成的溃疡比对照大鼠少。在AS范式的适应阶段，即在应激诱导之前，PS大鼠的活动量也仅为对照动物的一半左右。鉴于PS动物基线活动量的这种降低，本文讨论了将活动量用作衡量PS动物情绪指标的意义。还观察到了一些性别差异；雌性与雄性的不同之处在于：1）在AS实验的适应阶段和实验阶段，雌性均表现出较高的活动水平；2）相对肾上腺重量较重；3）达到牺牲标准所需的天数较少。
