Torres y Torres N
Departamento de Fisiología de la Nutrición, Instituto Nacional de la Nutrición Salvador Zubirán, México, D.F.
Rev Invest Clin. 1995 Mar-Apr;47(2):149-60.
The recent interest in the study of vitamin A is due to the discovery of an increasing variety of functions, actions or associations of this vitamin with cellular differentiation of epithelial tissues, growth, reproduction and vision. This review describes the recent advances on the metabolism of vitamin A especially in regard to the retinoid-binding proteins in the transport of hydrophobic retinoids and their participation in the transformation of the different retinoids in the organism as well as in the interior of the cell. Seven binding proteins have been discovered and well characterized: retinol binding protein (RBP); cellular retinol-binding protein (CRBP); cellular retinol-binding protein type two (CRBP-II); cellular retinoic acid binding protein (CRABP); cellular retinoic acid binding protein type two (CRABP-II); cellular retinal-binding protein (CRALBP) and interphotoreceptor retinol-binding protein (IRBP). Their specific roles are presented. Also the function and mechanisms of the regulation of gene expression by retinoic acid is described.
近期对维生素A研究的兴趣源于发现了该维生素越来越多的功能、作用或与上皮组织细胞分化、生长、繁殖及视觉的关联。本综述描述了维生素A代谢的最新进展，特别是关于疏水类视黄醇转运中的类视黄醇结合蛋白，以及它们在生物体和细胞内不同类视黄醇转化中的参与情况。已发现并充分表征了七种结合蛋白：视黄醇结合蛋白（RBP）；细胞视黄醇结合蛋白（CRBP）；细胞视黄醇结合蛋白II型（CRBP-II）；细胞视黄酸结合蛋白（CRABP）；细胞视黄酸结合蛋白II型（CRABP-II）；细胞视网膜结合蛋白（CRALBP）和光感受器间视黄醇结合蛋白（IRBP）。介绍了它们的具体作用。还描述了视黄酸对基因表达的调控功能和机制。
