Terreberry R R, Oguri M, Harper R M
Department of Anatomy and Cell Biology, University of California at Los Angeles 90024-1763, USA.
Sleep. 1995 Apr;18(3):139-44. doi: 10.1093/sleep/18.3.139.
Discharge patterns of 63 neurons in the bed nucleus of the stria terminalis (BNST) were cross-correlated with inspiratory onsets of the respiratory cycle and the R wave of the cardiac cycle in seven unrestrained, drug-free cats during waking (AW), quiet sleep (QS) and rapid eye movement (REM) sleep. BNST neurons fired slowly, with half having rates of less than 1/second; rates were higher in AW and REM states than in QS. Approximately one-quarter of cells showed a phasic discharge timing relationship with the respiratory cycle, and one-fifth with the cardiac cycle, in at least one sleep-waking state. Respiratory-cell correlations occurred more frequently during AW (18 cells) and QS (15) than REM (6), while cardiac-neuronal correlations preferentially developed during QS (13 cells) or REM sleep (11), with a smaller proportion during waking (7). Cardiac-cell discharge correlations were weaker than respiratory-cell correlations and much weaker during REM than during either AW or QS. The data suggest that sleep states modulate a respiratory-dependent neuronal discharge in this rostral site classically associated with affective functions, with the relationship being reduced during REM.
在七只未受束缚、未用药的猫处于清醒（AW）、安静睡眠（QS）和快速眼动（REM）睡眠状态时，终纹床核（BNST）中63个神经元的放电模式与呼吸周期的吸气起始以及心动周期的R波进行了交叉关联分析。BNST神经元放电缓慢，半数神经元的放电频率低于每秒1次；在AW和REM状态下的放电频率高于QS状态。在至少一种睡眠 - 清醒状态下，约四分之一的细胞与呼吸周期呈现相位放电时间关系，五分之一的细胞与心动周期呈现这种关系。呼吸 - 细胞相关性在AW（18个细胞）和QS（15个）期间比REM（6个）期间更频繁出现，而心脏 - 神经元相关性优先在QS（13个细胞）或REM睡眠（11个）期间形成，在清醒期间比例较小（7个）。心脏 - 细胞放电相关性比呼吸 - 细胞相关性弱，并且在REM期间比在AW或QS期间弱得多。数据表明，睡眠状态调节了这个传统上与情感功能相关的脑前部区域中依赖呼吸的神经元放电，且这种关系在REM期间减弱。
