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真核基因表达中的细胞质信使核糖核酸-蛋白质相互作用

Cytoplasmic mRNA-protein interactions in eukaryotic gene expression.

作者信息

McCarthy J E, Kollmus H

机构信息

Department of Gene Expression, National Biotechnology Research Centre (GBF), Braunschweig, Germany.

出版信息

Trends Biochem Sci. 1995 May;20(5):191-7. doi: 10.1016/s0968-0004(00)89006-4.

Abstract

Post-transcriptional mechanisms contribute in many important ways to the overall control and regulation of gene expression, and in doing so employ a veritable army of proteins that bind a wide range of targets in messenger RNA (mRNA). The full range of these RNA-protein interactions is only just beginning to emerge, and much remains to be learned about the mechanisms underlying the rapidly increasing number of regulatory systems now being described.

摘要

转录后机制在基因表达的整体控制和调节中发挥着多种重要作用,在此过程中,它动用了大量蛋白质,这些蛋白质可与信使核糖核酸(mRNA)中的多种靶标结合。这些RNA-蛋白质相互作用的全貌才刚刚开始显现,对于目前正在描述的数量迅速增加的调节系统背后的机制,仍有许多有待了解。

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