Peterka M, Tvrdek M, Likovský Z, Peterková R, Fára M
Institute of Experimental Medicine, Laboratory of Teratology, Academy of Sciences of the Czech Republic, Prague.
Acta Chir Plast. 1994;36(4):114-8.
It has been proposed that the hyperthermia in pregnant women may be associated with birth defects in their offsprings. We analysed the retrospective interview data on probable febrile illness during critical period of orofacial clefts development in 992 mothers of boys and girls with three types of orofacial clefts--cleft lip, unilateral or bilateral cleft lip and palate and cleft palate. A number of mother that gave the positive answer was relatively high and varied from 24% to 33%. There were no significant differences of the incidence of mother febrile illness between three groups of orofacial clefts in boys and girls. These data support presumption on the harmful effect of febrile illness during early pregnancy on craniofacial development.
有人提出，孕妇体温过高可能与她们后代的出生缺陷有关。我们分析了992名患有三种类型口腔颌面裂（唇裂、单侧或双侧唇腭裂以及腭裂）的男孩和女孩的母亲在口腔颌面裂发育关键期可能患发热性疾病的回顾性访谈数据。给出肯定回答的母亲数量相对较高，在24%至33%之间。男孩和女孩的三组口腔颌面裂中，母亲发热性疾病的发病率没有显著差异。这些数据支持了关于妊娠早期发热性疾病对颅面发育有害影响的推测。
